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Asian Pac J Cancer Prev. 2022 Apr 1;23(4):1215-1222. doi: 10.31557/APJCP.2022.23.4.1215.
OBJECTIVE: Lavender oil is of great economic importance. It has many biological and pharmacological activities. The present study aimed to identify the chemical constituents of Lavandula officinalis essential oil (LAEO) using GC/MS analysis. Its genotoxicity, anti-genotoxicity and histopathological activities against the chemotherapeutic drug cyclophosphamide (CP) were studied. The study also assessed its anticancer activities against six human cancer cell lines: hepatocellular carcinoma (HepG2), prostate (PC3), lung carcinoma (A549), skin cancer (A431), colon cancer (HCT116) and breast cancer (MCF7).
METHODS: Genotoxicity was determined using: micronucleus, chromosomal aberration and comet assays. The histopathological study included the liver. The groups examined were the negative control, the control plant, the positive control (CP) and 3 groups combined received LAEO at different concentrations plus CP.
RESULTS: GC/MS analysis recorded 16 components. The main ones were: linalool and linalyl acetate. The results indicated the safety of LAEO. It also attenuates the genotoxicity and deleterious histopathological effects of CP in a dose-dependent manner. LAEO has a highly cytotoxic effect on HepG2 and A549 cell lines with 100% death at 100 µg/ml with IC50 67.8 and 12 µg/ml, respectively. Its activity on other cell lines was weak.
CONCLUSION: The essential oil of Lavandula officinalis has an anti-cancer and anti-mutagenic effect.